We found that (1) circulatory total adiponectin and HMW adiponectin levels were significantly and inversely associated with the presence of calcified and non-calcified coronary plaques and (2) the HMW to total adiponectin ratio was significantly and inversely associated with the presence of low-attenuation coronary plaques in subjects with obstructive stable CAD. Here, ADIPOQ is linked to coronary artery disorder.