For example, for invasive breast cancer, premenopausal testosterone was not associated with premenopausal disease (OR: 1.1, 95% CI: 0.8 to 1.4), but was significantly associated with postmenopausal disease (OR: 1.8, 95% CI: 1.1 to 2.8) with a similar pattern for ER+/PR+ cancers, as well as for free testosterone. The gene discussed is ESR1; the disease is cancer.