Testosterone was not associated with breast cancer overall but was associated with invasive (5th vs. 1st OR: 1.4, 95% CI: 1.0 to 2.0, Ptrend = 0.23) and ER+/PR+ disease (5th vs. 1st quintile OR: 1.7, 95% CI: 1.1 to 2.6, Ptrend = 0.10) (Table 3). This evidence concerns the gene ESR1 and breast carcinoma.