Interestingly, NKX2-1 (more commonly known as Thyroid Transcription Factor-1 or TTF-1), a common immunohistochemical marker of lung adenocarcinomas [39,40], was among the top 20 classification markers and had higher expression levels in lung SCC compared to HNSCC cancers. The gene discussed is NKX2-1; the disease is head and neck squamous cell carcinoma.