Hence, filariasis which induce chronic inflammation and immunopathologic reactions through pro-inflammatory Th1 cytokines (IFN-gamma, TNF-alpha, GM-CSF, IL-1alpha, and IL-8) [20] or immunopathological-related brain tissue damage could be alleviated by downregulation neuroinflammation and excitotoxicity properties of mood stabilizers in conjunction with antihelmintics. Here, TNF is linked to filariasis.