Relaying on the findings that adiponectin related to proinsulin and HOMA cell function in diabetic subjects, it would be useful to find whether there is a possible role of adiponectin in mediation hepatic IR and decreased cell function in type 2 diabetes, as has been recently demonstrated that the interaction between muscle and hepatic receptors through activation of AMP kinase could mediate adiponectin effects [37]. This evidence concerns the gene INS and type 2 diabetes mellitus.