Adiponectin concentrations correlated significantly negative with HOMA B in subjects with type 2 diabetes only (r = −0.21, P = 0.04), whereas no significant correlation to HOMA IR was found in subjects with type 2 diabetes (r = 0.08, P = 0.44) or controls (r = −0.16, P = 0.33). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.