In the present study, we tested the likelihood of AGT polymorphism interacting with important cardiovascular risk traits, such as HTN, T2DM and obesity, contributing to disease pathways leading to atherosclerosis, following our previous finding of its linkage to early onset of CAD in heterozygous familial hyperlipidaemia (unpublished results). This evidence concerns the gene AGT and obesity due to melanocortin 4 receptor deficiency.