CXCR4 and neoplasm: The MIF expression levels in tumor cells and in TILs were significantly positively correlated with the CXCR4 expression levels in tumor cells and in TILs (P = 0.009, R = 0.224 and P = 0.026, R = 0.191, respectively), as shown in Figure 4A and 4B. Furthermore, the patients with the double high expression levels of MIF and CXCR4 in tumor cells had the worst DFS and OS compared to the patients with single high expression level of MIF or CXCR4 in tumor cells or double low expression level of MIF and CXCR4 in tumor cells (P = 0.002 and P = 0.006, respectively, Figure 4C and 4D).