The expression of TIM-3 has been found on tumor cells, including those from non-small cell lung cancers (NSCLCs), hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC), renal cell carcinoma (RCC) and follicular B cell non-Hodgkin’s lymphoma [11]. The gene discussed is HAVCR2; the disease is hereditary clear cell renal cell carcinoma.