Both cytokines are involved in the recruitment of neutrophils, granuloma formation and in anti-M.tb directed immune responses [10]; diminished Th1 and Th17 responses appear to be associated with higher rates of extrapulmonary TB [11]; vice versa, expression of SOCS3 is associated with increased IL-17 production along with T-cell exhaustion (in peripheral blood cells from patients with TB [12]. Here, SOCS3 is linked to tuberculosis.