Multivariate analysis including age and CRP as continuous metric parameters as well as sex, tumour stage, and differentiation identified the presence of lymph node and/or distant metastasis at the time of surgery (HR 4.24, 95% CI: 1.89-9.52; p<0.001, Cox regression), age [years] (HR 1.06, 95% CI 1.03-1.10, p<0.001), and the CRP-value [mg/l] (HR 1.01, 95% CI 1.004-1.02, p=0.001) as independent prognosticators for cancer-specific survival in patients with UUT-UC. The gene discussed is CRP; the disease is cancer.