At 100nM, 1,25(OH)2D3 exerted more extensive transcriptional effects, and at least 40 of the induced genes in breast cancer organotypic culture have already been reported as up regulated by the hormone, such as ALCAM, ARRDC4, BMP2, BMP6, CA2, CD14, CLIC6, CILP, CLMN, CYP19A1, DCLDB1, EFTUD1, EHBP1, FAM20C, FOXF1, FRAS1, GOS2, GRK5, HBGEF, HSMPP8, IL1RL1, KCNK3, KIAA0500, PKD2, RGNEF, SEMA6D, SERPINB1, SLC1A1, THBD, TIMP1, TRIM56[40,43-46]. The gene discussed is GRK5; the disease is breast cancer.