In addition, looking at overlapping genes in the Venn diagram of vitamin D up-regulated transcripts in six works [40,43-46], only seven intersections were found in non-cancer cells: AKR1B1, CRIP1, FZD8, MREG (in immortalized prostate cells and NAF), BCAT1, GCLC (in coronary artery smooth muscle cells and NAFs) and PRR6 (in immortalized prostate cells and coronary artery smooth muscle cells). The gene discussed is AKR1B1; the disease is cancer.