CD4 and AIDS: In a secondary analysis of Options in Management with Antiretrovirals (OPTIMA) data, Anis et al. (2009) [19] evaluated several treatment regimens in multidrug resistant HIV-infected adults and reported MOS-HIV scores for all treatment regimens collectively at baseline and at four follow-up time points, stratifying patients by presence or absence of AIDS-defining events (ADEs), serious adverse events (SAEs), and improvement in clinical measures—CD4 count and viral load.