TFPI2 and cancer: Recent studies show that the expression of TFPI-2 is down-regulated in several invasive tumor cell lines, including choriocarcinoma, glioma, prostate cancer, melanoma, fibrosarcoma, and pancreatic ductal adenocarcinoma, while exogenous expression of this gene in cancer cells can inhibit tumor growth and metastasis in vivo by modulating ECM remodeling and angiogenesis [11-16].