Secondly, a study in the Mediterranean population reported a positive association between fat intake and obesity in homozygotes for the T allele of APOA5 T-1131C, whereas in subjects carrying the APOA5 T-1131C polymorphism, higher fat intakes were not associated with higher BMI and TG-rich lipoproteins [26]. This evidence concerns the gene APOA5 and obesity due to melanocortin 4 receptor deficiency.