When the relative titres were compared to control cells (Figure 6B, HeLa, right, and BSR, left) that were infected but not transfected, cells expressing the dominant negative plasmid, Arf6/Q67L showed significant reduction in viral tires at 12 hrs (p < 0.0001 in HeLa and p = 0.0007 in BSR) post-infection, but not at 4 hrs (p = 0.01 in HeLa and p = 0.2 in BSR). This evidence concerns the gene ARF6 and infection.