Furthermore we hypothesized that the two single nucleotide polymorphisms (SNPs) of TLR2-gene (Arg677Trp and Arg753Gln) and TLR4-gene (Asp299Gly and Thr399Ile) are implicated in the pathogenesis of JIA and SLE. The gene discussed is TLR2; the disease is systemic lupus erythematosus.