We examined the presence of TLR2 and TLR4 proteins on peripheral CD14+ blood monocytes of 65 JIA patients [(19 patients with systemic JIA (3 children under flare), 28 patients with oligoarthritis (3 children under flare), 9 patients with seronegative polyarthritis (3 children under flare) and 11 patients with enthesitis related arthritis (3 children under flare)] and 9 SLE patients (1 patient under flare) as well as 67 healthy individuals by flow cytometry analysis. Here, TLR2 is linked to polyarticular arthritis.