CD4 and myopathy: The vaccination regimen used in our experimental model induced a cell-mediated immunity characterized by lymphoproliferation, as well as the enhanced production of IFN-γ, which was in agreement with the results from Cazorla et al. who studied mice immunized with a T. cruzi recombinant cruzipain (rCz); they measured the abundance of rCz-specific IFN-γ secreting- CD8+ T-cells in splenocytes depleted of CD4+ lymphocytes, and survival, efficient control of parasite load and restricted inflammatory myopathy were demonstrated [35].