As shown in Figure 2, we confirmed the overexpression of CAPN6, GALA1 and MT2A in the medulla oblongata in clinical stage scrapie-infected animals, as well as the downregulation of COL1A2, COL3A1 and MTNR1B. In general, this profile was maintained in the other CNS regions of clinical sheep. This evidence concerns the gene COL3A1 and scrapie.