CAPN6 and scrapie: As shown in Figure 2, we confirmed the overexpression of CAPN6, GALA1 and MT2A in the medulla oblongata in clinical stage scrapie-infected animals, as well as the downregulation of COL1A2, COL3A1 and MTNR1B. In general, this profile was maintained in the other CNS regions of clinical sheep.