In addition to our previous study showing the overexpression of the Calpain 6 gene in the medulla oblongata of terminal scrapie [20], other members of the calpain family have been associated with prion diseases [59,60] and other neuropathological events, contributing to Alzheimer’s [61-63] and Parkinson’s [64]. Here, CAPN6 is linked to Parkinsonism.