In summary, we present here the gene transcription data and immunohistochemical protein distributions for CAPN6, COL1A2, COL3A1, GALA1, MTNR1B and MT2A in various regions of the CNS based on a large set of sheep with naturally occurring classical scrapie, including both the clinical and preclinical stages of the disease. This evidence concerns the gene COL3A1 and scrapie.