The expression of COL1A2 transcripts was strongly downregulated in the medulla oblonga of scrapie animals both here and in our previous study, suggesting a role in prion neuropathology since this region includes a circumventricular organ, the area postrema, which is enriched in different collagen types and one of the potential entrances of the prions into the brain [45]. The gene discussed is COL1A2; the disease is scrapie.