PCNA and Cirrhosis: Hepatocytes of liver tissues from the cirrhosis rats of Group 2 showed down-regulation of Bax staining (Figure 15A-15I) with up-regulation of Bcl2-positive hepatocytes (Figure 15B-15I) and more PCNA staining (Figure 16B) indicating severe damage with increased number of necrotic cells than their apoptosis.