The polymorphisms rs4696480 and rs1898830 in TLR2 and the polymorphisms rs2770150, rs10759931, rs6478317, rs10759932, and rs1927911 in TLR4 increased the effect of fine particulate matter exposure on the prevalence of doctor-diagnosed asthma from birth up to eight years of age. The gene discussed is TLR4; the disease is asthma.