Although the patients in immunophenotypic cluster group II had a higher incidence of FLT3-ITD, a mutation associated with poor prognosis [31], Cox regression multivariate analysis revealed that the immunophenotypic cluster was an independent prognostic factor (RFS, p < 0.001; OS, p = 0.001) in AML patients with NPM1 mutations. The gene discussed is NPM1; the disease is acute myeloid leukemia.