Anti-CSP antibodies correlate with protection against infection in malaria naïve adult challenge studies [28] and field studies in young children [30], against clinical malaria in trials with young children in Kenya/Tanzania [31] and in Gabon/Ghana/Tanzania [32], but anti-CSP antibodies did not correlate with protection against clinical malaria in a trial with older children in Mozambique [33]. This evidence concerns the gene DNAJC5 and malaria.