DDX10 and leukemia: The only events that disrupted the same genes in two tumors were translocations t(11:13)(q22.3,q12.11), which breakpoints were located within the genes SKA3 and DDX10. SKA3 is required for spindle checkpoint silencing, the maintenance of chromosome cohesion in mitosis and metaphase to anaphase progression [18,19], whereas DDX10 encodes a DEAD-box RNA helicase and is known to form an NUP98-DDX10 fusion oncogene in leukemia [20].