SKA3 and neoplasm: In order to gain insight into the functional role of some of these genes in tumor cell growth, we performed small interfering RNA (siRNA) knock-down analysis targeting candidate genes CLTC (clathrin, heavy chain), EPHA5 (EPH receptor A5), SKA3 (spindle and kinetochore associated complex subunit 3), DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10) and TNIK (TRAF2 and NCK interacting kinase).