DACT2 and neoplasm: The average level of DACT2 mRNA expression in HCC tissues was 2.25-fold lower than in adjacent noncancerous tissues (4.68 ± 6.96 vs. 10.55 ± 14.6; P < 0.05) as shown in Figure 1A. DACT2 protein expression was also investigated by immunohistochemistry in tumor tissues and the nontumoral liver counterparts (n = 26), as is shown in Figure 1B,C,D.