In order to identify patients with thyroid cancer who require early intervention, many predisposing factors for malignancy have been recognized, including young age (<20 years old) or older age (>70 years old), male gender, large (>4 cm) or rapidly growing nodules, and history of radiation exposure, calcification and thyroglobulin (Tg) [4-7]. This evidence concerns the gene TG and thyroid cancer.