NCAM1 and neuroblastoma: Specific inhibition of NCAM release from the membrane by blocking metalloproteinase cleavage (using inhibitors BB-3103 or GM 6001) resulted in aggregation of neurones in primary hippocampal neurones in culture and NCAM-140 expressing B35 neuroblastoma cells (Diestel et al. 2005; Hubschmann et al. 2005).