(BxS)F1 females also suffered less from LPS-induced hypothermia (Fig 1B) and produced less IL6 (p = 0.0014) (Fig. 1C) and other cytokines and chemokines (Fig 1D) than (BxS)F1 males, which indicates that they are less sensitive to acute endotoxemia. Here, IL6 is linked to serum lipopolysaccharide activity.