DUSP1 and Sepsis: For example, the prominent role of the GC-induced GRE-gene Dusp1 (encoding dual specific phosphatase 1) in the control of excessive inflammation has been confirmed in Dusp1 deficient mice, which are very sensitive for LPS and TNF-induced lethal inflammation (Vandevyver et al, 2012; Zhao et al, 2005) and in other sepsis models (Frazier et al, 2009; Hammer et al, 2010).