Endpoints were DFS, overall survival (OS), time to recurrence (TTR), time to distant recurrence (TTDR), safety and tolerability, cumulative incidence of brain metastases as the first site of breast cancer recurrence, presence or absence of cMyc gene amplification, expression levels of PTEN, and presence or absence of p95 HER2 domain. This evidence concerns the gene ERBB2 and breast cancer.