In contrast to previous studies which show that tauopathy can evoke neuronal degeneration but cannot form neurofibrillary tangles in other types of neurons in Drosophila and Caenorhabditis [24, 56]; our results suggest that human tau can produce tangle pathology in DA neurons, similar to the tau neurofibrillary tangles seen in PD patients. Here, MAPT is linked to tauopathy.