CALB2 and Huntington disease: Only in Guinard-Samuel’s study a large series of rectal suction biopsies were used to assess the diagnostic value of calretinin IHC in the diagnosis of HD (15).We evaluated different layers of bowel (lamina propria, muscularis mucosa and muscularis propria) separately, and explored the results in cases with different extents of HD (although the number of cases in each type of HD were limited), which were not addressed in the previous studies.