Regarding the particular feature of GC-induced dyslipidemia (high HDL-c levels), The present study was conducted to evaluate effects of niacin on dyslipidemia and fatty changes of liver due to dexamethasone, a potent GC receptor agonist with insignificant mineralocorticoid receptor activity, in rats as a frequently used animal model for dyslipidemic conditions. This evidence concerns the gene NR3C2 and metabolic syndrome.