In mouse model of alcoholic liver diseases that oxidative stress and inflammation were the main causes of the pathogenesis, silymarin was observed to pose hepatoprotective effects by producing the tumor necrosis factor (TNF) and decreasing the serum alanine aminotransferase (ALT) activity, which inhibits lipid peroxidation, and increases the intracellular GSH content (6). Here, TNF is linked to alcoholic liver diseases.