DDIT3 and non-Hodgkin lymphoma: In 2005, Nakame et al. (2005) aimed to characterize acute CHOP (cyclophosphamide, doxorubicin, Vincristine, and prednisolone) induced cardiotoxicity using echocardiography, ECG as well as serum cardiac markers in order to evaluate whether or not Angiotensin II type 1 receptor blockers (ARBs) can prevent acute CHOP induced cardiotoxicity in patients with Non-Hodgkins Lymphoma (NHL).