BSG and malaria: Available evidence suggests that “outside-in” signaling may be required for the malaria parasite invasion (Singh et al., 2010; Chen et al., 2011; Riglar et al., 2011), but it remains to be determined if the structural framework that supports erythrocyte invasion through CD147 is distinct from, or overlaps with, the epitope on the CD147 ectodomain that senses signals transduced to endothelial and other cells that express this molecule.