For KSHV-infected individuals, one implication of these molecular associations could be that virus-induced upregulation of CD147 (as we and others have shown; Qin et al., 2010; Dai et al., 2012a,b), could stabilize CD147-containing multi-partite complexes and in turn potentiate their drug efflux functions, which could blunt the efficacy of chemotherapeutic strategies that might be used in the treatment of KS and other virus-associated malignancies. The gene discussed is BSG; the disease is Kaposi's sarcoma.