In support of this view, Qin et al. (2011) recently showed that the intrinsic resistance of KSHV-positive peripheral effusion lymphomas to the cytotoxic effects of paclitaxel and doxorubicin depends on orchestrated interactions of CD147 with lymphatic vessel endothelial receptor 1 (LYVE-1) and the homodimeric ATP-binding cassette (ABC)-G2/BCRP (breast cancer resistance protein) drug transporter that is highly expressed on the surface of primary effusion lymphoma (PEL)-derived cell lines. Here, LYVE1 is linked to primary effusion lymphoma.