Signaling events transduced through CD147 are associated with survival, metastasis, and invasion of a variety of cancer cells, mainly because it stimulates enhanced stromal release of multiple matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF), which are among the key mediators of angiogenesis and metastatic transition (Marieb et al., 2004; Tang et al., 2005; Bougatef et al., 2009; Kanekura and Chen, 2010). The gene discussed is BSG; the disease is cancer.