It is also insightful that the KSHV lytic cycle was activated only by the PfEMP-1-CIDR1α-derived peptide from Pf Malayan Camp strain, but not by peptides derived from the Vietnam Oak Knoll (FVO) or A4tres strain [that preferentially binds intercellular adhesion molecule 1 (ICAM-1) and not CD36] (Figure 2C), demonstrating that reactivation of KSHV by the parasite ligand displays some degree of strain specificity for Pf that is associated with severe malaria in Africa. This evidence concerns the gene ICAM1 and malaria.