While a study assessing levels of Ucn1 and 2 has not found any significantly changes in patients suffering from major depressive disorder vs. controls (Kang et al., 2007), Ucn1 mRNA is markedly upregulated in the EWcp in depressed male suicide victims, compared to healthy males (Kozicz et al., 2008). The gene discussed is UCN; the disease is major depressive disorder.