Thus, recent studies with the V1b receptor knockout mice demonstrated reduced plasma levels of ACTH and corticosterone or only ACTH in response to insulin-induced hypoglycemia (Lolait et al., 2007), forced-swimming (Tanoue et al., 2004; Stewart et al., 2008), novel environment (Stewart et al., 2008), mild restraint (Stewart et al., 2008), and in response to some of the other stressors (Roper et al., 2011) compared to wild-type mice. The gene discussed is INS; the disease is Hypoglycemia.