More recently, it was demonstrated that MVs derived from human cancer cells (i.e., breast carcinoma and glioma cells) may play an important role in oncogenesis, as they were shown to be capable of transforming normal fibroblasts and epithelial cells to adopt the typical cancer cell characteristics (e.g., anchorage-independent growth and enhanced survival capability) through the transfer of the cross-linking enzyme tissue-transglutaminase (tTG) [16]. Here, TGM2 is linked to central nervous system cancer.