About 70–80% of mesothelioma specimens possess deficiency in the INK4A/ARF locus containing p16 INK4A and p14 ARF genes [12], about 40% in neurofibromatosis type 2 gene (NF2) [13] and about 10% in BRCA1 associated protein-1 (BAP1) gene [14]. This evidence concerns the gene CDKN2A and mesothelioma.