Consistent with the observation that NHE1 inhibition can reduce ventricular arrhythmias [20, 21], the present study found that NHE1 inhibition with sabiporide dose-dependently reduced ventricular premature beats and ventricular tachycardia and prevented ventricular fibrillation and early death. The gene discussed is SLC9A1; the disease is ventricular fibrillation.