IL4 and type 1 diabetes mellitus: The main mechanisms involved in the abrogation of EAE and T1D with T. crassiceps infection may be IL-4 and IL-10 secretion as well as the induction of anergy in lymphocytes, as it has been shown that these diseases are dependent upon autoreactive lymphocyte proliferation [88, 89] and commitment to Th1 and Th17 subsets [90].