Interestingly, we have previously demonstrated that monocyte-enriched mononuclear cells from individuals with type 2 diabetes show increased levels of visfatin, resistin, TNF-α, IL-6, and IL-1β mRNA expression indicating that hyperinsulinemia and hyperglycemia could enhance cytokine production [8, 31]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.