CXCR4 and diabetes mellitus: If the animals-derived evidence that a high fraction of the wound myofibroblasts potentially derives from bone marrow fibrocytes is valid for humans [105]; we have already learned that diabetes negatively impacts on the general bone marrow physiology [106] and that beyond this, stromal-derived factor-1alpha (SDF-1α), which acts as a recruiting factor and its CXCR4 chemokine receptor are also impaired by diabetes [107].