However, when the methylation percentages of HOXA4 were categorized into two classes, 1–49% as methylated and 50–100% as hypermethylated and the values were compared, HOXA4 hypermethylation was significantly higher among IM-resistant CML patients (P = 0.002) than IM good response CML patients. The gene discussed is HOXA4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.