A study by Pineda et al., 2005, [10] determined the role of STF in regulating the immune response using the mouse model of pleomorphism malignancy glioma and revealed that STF increases the number of CD2, CD4, CD8, and NK cells; it enhances the apoptosis of number of tumor cells and the expression of Th1 subpopulation in tumor tissue. This evidence concerns the gene CD4 and central nervous system cancer.