TLR2 and bacterial urinary tract infection: To extend our previous analysis of genetic polymorphisms in pediatric patients with renal parenchymal infections [12], this study explored the correlations between polymorphisms in UTI-related TLR genes (TLR-1, TLR-2, TLR-4, TLR-5, and TLR-6) and clinical severity among pediatric patients with UTIs of different severities (APN and the clinically more severe disease, ALN).