Our previous study showed a strong association of PNPLA3 gene with the occurence of NAFLD [17], and we were therefore curious to find out whether there is any gene-gene interaction between PNPLA3 and AGTR1. The results with the two-locus and three-locus models are shown in Table 4. This evidence concerns the gene AGTR1 and metabolic dysfunction-associated steatotic liver disease.