While none of the well-differentiated primary tumors (grade 1) and only 41% of moderately differentiated carcinoma cells (grade 2) exhibited strong staining intensities; however, about 80% of the poorly differentiated (grade 3) and 87% of lymph node metastatic tumors exhibited strong staining for RIG-I (*P<0.01, Chi-square test). Here, RIGI is linked to metastatic malignant neoplasm in the lymph nodes.