LEP and obesity due to melanocortin 4 receptor deficiency: In white adipose tissue, we found significant down regulation of Glut4, a gene whose loss in adipose tissue results in hyperglycemia and impaired glucose handling [29], [30]; leptin a gene whose product enhances peripheral glucose uptake [31] and perilipin, a white adipose protein whose over expression protects from diet induced obesity and improves glucose tolerance [32].