The major findings are: i) Fgl1was expressed in low levels in adipose tissue but that this expression is augmented following liver injury ii) Fgl1 null mice had lower fasting plasma concentrations of cholesterol and free fatty acids iii) Fgl1 null mice exhibited fasting hyperglycemia and enhanced hepatic glucose production iv) Fgl1 null mice were heavier than wild type mates despite consuming similar amounts of food. The gene discussed is FGL1; the disease is Hyperglycemia.