In addition, the therapeutic effect of recombinant human erythropoietin (rhEPO) on the subsequent vasospasm after subarachnoid hemorrhage may relate to its inhibition of endothelial apoptosis in cerebral arteries, which may be mediated in part by the JAK2/STAT3 signaling pathway [37]. The gene discussed is EPO; the disease is subarachnoid hemorrhage.