COL3A1 and Hepatic fibrosis: Hepatic fibrosis/hepatic stellate cell activation, which is one of the more interesting canonical pathways identified in our study, receives stimuli that could simultaneously activate COL3A1, FGFR1, and IGFBP5. Hepatic fibrosis is a chronic liver disease associated with extracellular matrix accumulation and is thus similar to the ULs pathological condition.