IGFBP5 and neoplasm: A significant association was found between the age at diagnosis and age at first pregnancy for the FGFR1 (P = 0.0211) and IGFBP5 (P = 0.0416), respectively (Figure S1-B), whereas increased expression of FGFR1 and IGFBP5 was more frequently identified in tumours from young patients (<40 years of age) and patients who became pregnant before 21 years of age.